Building the Future of Evidence-Based Mental Health Care

MindStreet pioneers clinically validated digital therapeutics that make mental health care accessible, effective, and stigma-free — anytime, anywhere.

Founded by leaders in cognitive behavioral therapy (CBT), technology, and clinical research, MindStreet brings together more than 25 years of NIH-funded innovation in computer-assisted therapy. Our mission is simple:

To help people think better, feel better, and live better — using science, empathy, and technology.

Our Mission: To Bridge the Gap Between Mental Health Needs and Access

Mental health challenges are at an all-time high, but access to effective treatment remains limited. MindStreet exists to close this gap by transforming decades of proven cognitive behavioral therapy research into scalable, digital solutions that meet people where they are.

We envision a world where evidence-based therapy is no longer a privilege, but a right — available to anyone in need, regardless of location, stigma, or cost.

From Research to Real-World Impact

MindStreet's origins lie in groundbreaking work by Dr. Jesse Wright (University of Louisville) and Dr. Michael Thase (University of Pennsylvania), pioneers of computer-assisted cognitive behavioral therapy (CCBT). Their NIH-funded research demonstrated that digital CBT could achieve outcomes equivalent to in-person therapy with significantly reduced clinician time and cost.

Building on this foundation, MindStreet was created to translate those clinical successes into accessible, enterprise-ready digital therapeutics. Our flagship program, Good Days Ahead™, integrates human insight and digital precision — delivering personalized CBT experiences for individuals, employers, providers, and payors worldwide.

"What began as an academic breakthrough has become a movement — expanding access to evidence-based care for millions."

Led by Experts in Clinical Science and Technology

Our leadership team brings together expertise in psychiatry, digital therapeutics, clinical psychology, and business innovation — ensuring that every MindStreet solution meets the highest standards of scientific rigor, usability, and patient privacy.

Valerie Mukherjee

Co-Founder & Executive Chair

20+ years in digital health strategy and commercialization; leads MindStreet's vision for expanding global access to mental health care.

Brian Mayhugh, Ph.D.

Co-Founder & Chief Scientist

Clinical psychologist with 30+ years of CBT experience; directs scientific development and clinical validation.

Dr. Jesse Wright, M.D., Ph.D.

Co-Founder & Chief Clinical Advisor

Professor of Psychiatry at University of Louisville; pioneer of CCBT and principal investigator in multiple NIH trials.

Dr. Michael Thase, M.D.

Scientific Advisor

Professor of Psychiatry at the University of Pennsylvania; leading authority on CBT and depression treatment.

Nora Betancourt

Chief Operating Officer

Oversees implementation and clinical partnerships ensuring data integrity and patient engagement.

Samuel McHugh, Ph.D.

Director of Clinical Research

Focuses on efficacy measurement, patient outcomes, and evidence translation.

Delivering Proven, Scalable, Digital CBT Solutions

MindStreet transforms evidence into outcomes — combining research, technology, and compassion.

Digital Therapeutics (DTx)

Software-based treatments for depression, anxiety, and stress that are clinically validated and FDA-aligned.

Good Days Ahead™ Platform

A comprehensive digital CBT system that delivers structured lessons, interactive exercises, and clinician oversight for measurable improvement.

Enterprise Solutions

Tailored programs for employers, health plans, providers, and universities — reducing costs, improving access, and boosting engagement.

Data & Analytics

Integrated reporting tools that track progress, outcomes, and ROI.

Where Clinical Evidence Meets Human Results

Our platform has helped thousands of individuals manage depression, anxiety, and stress more effectively — while enabling organizations to expand access and reduce care costs.

25+

Years of NIH-funded research

3%

Randomized controlled trials validating efficacy

84%

Completion rate across user cohorts

Greater efficiency than traditional therapy

Every MindStreet program is guided by our commitment to measurable, lasting change.

Partnering With the World's Leading Institutions

We collaborate with universities, hospitals, and research organizations to continue advancing the science of digital therapeutics. Our research partnerships include:

University of Pennsylvania
University of Louisville
Yale University
University of Michigan
Purdue University
Indiana University

Join Us in Redefining Mental Health Care

We're always looking for passionate individuals — clinicians, data scientists, designers, and engineers — who share our mission of making evidence-based therapy accessible for all.

View Open Roles Contact Us

Let's Build a Healthier, More Resilient World — Together

Partner with MindStreet to bring proven, evidence-based digital therapy to your organization. Whether you're a provider, employer, or researcher, we'll help you scale access to care that truly works.

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